Pineapple Express is a sativa-dominant hybrid made by crossing Trainwreck with Hawaiian. It produces long-lasting energetic effects that are typically quick to onset. Pineapple Express is known to illicit feelings of creativity and alertness, with a relaxed disposition, and as such, is best suited for daytime to late-afternoon use. In terms of flavor, Pineapple Express exudes bright citrus notes infused with pineapple and earthy pine, thanks to its varied terpene profile. Medical marijuana patients choose Pineapple Express to relieve symptoms associated with depression, anxiety, pain, and fatigue.